Could inflammation and cell death be the cause of psoriasis?
Research from Mr James Rickard, Associate Professor John Silke and colleagues from the Walter and Eliza Hall Institute has revealed a previously undiscovered link between inflammation and cell death.
It has been known for some time that cells undergo a programmed death to ensure that damaged, unneeded or dangerous cells are removed from the body. The process is designed to ensure that the organism grows and develops in a naturally, organized manner. This is known as apoptosis.
Another type of cell death known as Necroptosis has been discovered. Necroptosis is believed to be linked to inflammation and eventually inflammatory related disease such as psoriasis and Crohn’s disease. Necroptosis occurs when something has gone wrong with apoptosis. Because necroptosis is occurring due to an apoptosis problem, the immune system is triggered and inflammation takes place.
Apoptosis has previously been considered to be a beneficial and harmless step in our ageing and regeneration process. It has not previously been linked to inflammation or skin disease, so the research findings were unexpected. Necroptosis was found to be linked to problems of larger organs such as the liver and spleen, but not the skin.
The implications of these findings may explain why the use of natural or medical anti-inflammatory agents can be useful in the treatment of psoriasis.
Other signs of inflammation in psoriasis
For some people, psoriasis is not just a skin or nail disorder. Psoriatic arthritis is quiet common as are links to other degenerative diseases such as metabolic syndrome. Psoriatic arthritis is a painful condition affecting the large joints. Anti-inflammatories are very useful for pain relief when arthritis is present.
Metabolic syndrome, a condition that is closely linked to heart disease and diabetes– is largely triggered by inflammation (or the fire within).Taking an anti-inflammatory for the treatment of psoriasis can therefore be useful for multiple different health issues.
The use of a natural anti-inflammatory is therefore an obvious step in a successful, long term treatment for psoriasis.
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Explore further: Link found between cell death and inflammatory disease
More information: “TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.” DOI: dx.doi.org/10.7554/eLife.03464 Journal reference: eLife
Provided by Walter and Eliza Hall Institute of Medical Research